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Berberine Supplement Market Outlook ( to )

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Projections by Fact.MR for the global berberine supplement market indicate a value of US$ 897.6 million in and an increase to US$ 2.05 billion by the end of , which amounts to a CAGR of 8.6% for the next ten years.

Growing consumer awareness of natural health supplements and their potential benefits is driving sales of berberine supplements. Berberine is a compound that is found in many plants, including Oregon grape, barberry, and goldenseal. It has been the subject of much research because of its potential health benefits, especially in heart health and blood sugar regulation. It is currently gaining popularity as a supplement and medication substitute for heart-related conditions.

The two main causes of death globally are metabolic diseases (such as diabetes, obesity, and non-alcoholic fatty liver disease) and cardiovascular diseases (such as atherosclerosis, myocardial infarction, hypertension, cardiac hypertrophy, and heart failure).

• According to A study supported by the National Center for Complementary and Integrative Health revealed that individuals receiving metformin along with a goldenseal supplement experienced a 25% reduction in their blood levels of the diabetes medication (goldenseal contains berberine).

Consequently, berberine can lower blood sugar control in people with type 2 diabetes taking metformin or other diabetes medications. Researchers have linked the weight loss benefits of berberine's antioxidant properties to its potential to stop the formation of fat cells.

Key Market Growth Drivers

• Consumers are increasingly turning to natural alternatives or traditional pharmaceuticals to treat a variety of health conditions.
• Due to diseases such as diabetes, obesity, and cardiovascular conditions, consumers are looking for dietary supplements with potential health benefits.
• Health benefits of berberine, such as its ability to reduce heart disease risk, maintain a healthy weight, and regulate blood sugar and cholesterol imbalance, are major factors driving the growth of the berberine supplement market.
• Easy accessibility of such supplements through a wide range of distribution channels, such as pharmacies, health food stores, and online retail platforms is also driving market expansion.
• Berberine supplements are useful in the management of chronic health conditions among the aging population.
• Safety and potential benefits of berberine supplements are being recognized by regulatory bodies in several regions.

Report Attributes Details Berberine Supplement Market Size (E) US$ 897.6 Million Forecasted Market Value (F) US$ 2.05 Billion Global Market Growth Rate ( to ) 8.6% CAGR North America Market Share (E) 20.4% Retail Sales Market Share (E) 75.36% Sales of Berberine Supplement Tablets (E) US$ 168 Million Key Companies Profiled Solaray; Zhou Nutrition; Swanson Health; Sunergetic; Best Naturals; Horbaach; Thorne; Toniiq; Now Foods; Amazing Nutrition; Dr Martins Nutrition

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What are the Key Berberine Supplement Market Trends?

&#;Companies Promoting Benefits of Berberine Supplements in Efficient Manner&#;

Consumers are becoming more aware of the possible health benefits of berberine supplements, particularly in the treatment of diabetes, high cholesterol, and obesity.

Rising sales of these supplements have resulted from increased consumer awareness. Manufacturers are coming up with new ideas to differentiate their supplements from competitors. This involves creating new formulations, such as combination products that include complementary ingredients for increased efficacy or sustained-release capsules.

Organizations are employing specific advertising strategies to establish relationships with particular consumer segments, such as those who have an interest in natural health supplements for the management of diabetes.

Businesses can effectively enhance the promotion of their berberine supplements and increase revenue by adjusting their marketing strategies to resonate with their target audience. Recent research has explored the potential of berberine as a pharmaceutical intervention for obesity.

• According to ScienceDirect, berberine prevents the accumulation of fat in human and murine adipocytes. Berberine supplements substantially decrease body weight, body mass index, and visceral fat. They also play a role in lowering C-reactive protein levels.

Which Obstacles are Impeding Market Expansion?

&#;Lack of Regulation by FDA for Berberine Supplements&#;

To verify berberine's potential health advantages, as well as its safety and effectiveness in treating a range of human illnesses, medical professionals advise against its use.

Side effects such as constipation, headaches, rash, nausea, and upset stomach can occur with berberine. Prescription drugs, including those that lower blood sugar, may interact with berberine and cause harmful side effects.

The United States FDA does not regulate supplements like berberine, so it is never known how much of the active ingredient is in a product. Supplements containing berberine can vary greatly in composition, leading to confusion regarding dosage. Berberine use in pregnant women and newborns can have negative consequences.

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Country-wise Insights

In , Japan rose to prominence as a key berberine chloride exporter. Since berberine chloride is a hydrochloride and ammonium salt form of the herb, it may be used to combat diabetes and inflammation. Based on export data from Japan, the country was the leading supplier of berberine chloride to India in .

Because of its excellent clinical and safety profile, berberine is widely used in Asian countries, primarily in China. It is regarded as one of the most promising natural product-derived drugs for the treatment of CVMD due to advancements in pharmacological research.

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Why are Sales of Berberine Supplements High in China?

&#;Long History of Berberine Use in Treating Diabetes&#;

Attribute China Market Value (E) US$ 117.9 Million Growth Rate ( to ) 10.8% CAGR Projected Value (F) US$ 327.7 Million

Expansion of the berberine supplement market size in China is driven by its extensive history in herbal and Chinese medicine. Berberine has been used for years to treat diabetes in China. Cases of diabetes among the population in China recorded a 10.5% year-over-year increase in .

• For instance, berberine improves the effectiveness of probiotic powder when both are taken together to lower blood sugar levels in people with diabetes, according to the results of a clinical trial with 409 participants by Premote.

Why are Berberine Supplement Providers Investing in the United States?

&#;Shift toward Herbal Remedies Due to Concerns over Adverse Effects of Conventional Drugs&#;

Attribute United States Market Value (E) US$ 155.8 Million Growth Rate ( to ) 7.5% CAGR Projected Value (F) US$ 320.1 Million

In the United States, retail sales of vitamin and mineral products experienced an approximate annual growth rate of 1% from to .

• According to a survey by the Council for Responsible Nutrition (CRN), 69% of adults in the country take dietary supplements to address nutritional deficiencies.

As berberine is classified as a dietary supplement, the increasing popularity of nutritional supplements is projected to significantly drive market expansion. Berberine, being an alkaloid compound, is present in various herbs. With growing concerns over the adverse effects of pharmaceutical drugs, there has been a shift towards herbal remedies. Therefore, the herbal characteristics of berberine play a crucial role in determining its demand in the country.

Category-wise Insights

The berberine supplement market is growing due to the preference for quick-absorbing, vegan-friendly supplements among the health-conscious population, as well as the proven benefits of berberine in managing a variety of health conditions.

Why are Online Sales of Berberine Supplements Rising at a Significant Pace?

&#;Easy and Extensive Availability of Berberine on e-Commerce Platforms&#;

Attribute Online Sales Market Value (E) US$ 221 Million Growth Rate ( to ) 8.1% CAGR Projected Value (F) US$ 483 Million

Berberine supplements typically cost between US$ 15 and US$ 40 for a month's supply and are readily available online. In certain countries, such as the United States, plants containing berberine are not found locally. However, these supplements are widely available online. The demand for supplements like berberine is increasing due to the growing trend towards natural alternatives and increased health consciousness among netizens.

Why Do Tablets Account for a Leading Berberine Supplement Market Share?

&#;Immediate Absorption of Tablets by Body Driving Their Preference&#;

Attribute Tablets Market Value (E) US$ 168 Million Growth Rate ( to ) 5.4% CAGR Projected Value (F) US$ 283 Million

Demand for berberine supplements in tablet form is rising significantly due to their quick absorption by the body, making them the preferred option among many consumers. Consistent dosing, facilitated by tablets, ensures that users effectively achieve the desired effects.

Another reason for the growing sales of berberine supplements is that an increasing number of consumers are shifting to plant-based and vegan products, and berberine capsules meet this requirement as they do not contain any substances derived from animals.

Know thy Competitors

Competitive landscape highlights only certain players
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Leading Market Players

Key players in the berberine supplement industry are Solaray, Zhou Nutrition, Swanson Health, Sunergetic, Best Naturals, Horbaach, Thorne, Toniiq, Now Foods, Amazing Nutrition, and Dr Martin&#;s Nutrition.

Segmentation of Berberine Supplement Market Research

• By Form :

  • Caplets
  • Capsules
  • Liquid
  • Powder
  • Softgel
  • Tablets

• By Sales Channel :

  • Online
  • Retail

• By Region :

  • North America
  • Europe
  • Latin America
  • East Asia
  • South Asia & Oceania
  • Middle East & Africa

Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular diseases affecting vasculature in the heart, cerebrovascular disease, atherosclerosis, and diabetic complications have compromised quality of life for affected individuals and increase the burden on health care services. Berberine, a naturally occurring isoquinoline alkaloid form Rhizoma coptidis, is widely used in China as a folk medicine for its antibacterial and anti-inflammatory properties. Promisingly, an increasing number of studies have identified several cellular and molecular targets for berberine, indicating its potential as an alternative therapeutic strategy for vascular diseases, as well as providing novel evidence that supports the therapeutic potential of berberine to combat vascular diseases. The purpose of this review is to comprehensively and systematically describe the evidence for berberine as a therapeutic agent in vascular diseases, including its pharmacological effects, molecular mechanisms, and pharmacokinetics. According to data published so far, berberine shows remarkable anti-inflammatory, antioxidant, antiapoptotic, and antiautophagic activity via the regulation of multiple signaling pathways, including AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), mitogen-activated protein kinase silent information regulator 1 (SIRT-1), hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), janus kinase 2 (JAK-2), Ca 2+ channels, and endoplasmic reticulum stress. Moreover, we discuss the existing limitations of berberine in the treatment of vascular diseases, and give corresponding measures. In addition, we propose some research perspectives and challenges, and provide a solid evidence base from which further studies can excavate novel effective drugs from Chinese medicine monomers.

In recent years, novel unique molecular entities derived from herbal medicines containing berberine have led to increased attention to the potential of this compound in the treatment of vascular diseases ( Lee et al., ; Ren et al., ; Rajabi et al., ). Along with advances in pharmacological research, berberine was considered one of the most promising naturally derived drugs for the treatment of numerous human vascular diseases through the modulation of multiple signaling pathways. However, no systematic reviews on the pharmacological and pharmacokinetic properties of berberine in the context of vascular disease have been published. Therefore, in this review, we screened articles on berberine treatment in vascular diseases published in the years &#; using Web of Science, ScienceDirect, PubMed, Google Scholar and China National Knowledge Infrastructure online databases and summarized the findings to provide insights into the potential application of berberine in vascular diseases.

Pharmacokinetics of Berberine

Distribution

It has been demonstrated that berberine is rapidly distributed through tissues in the liver, kidneys, muscle, lungs, brain, heart, pancreas, and fat, in descending order of amount, while the concentration of berberine in most of these tissues was higher than that in plasma 4 h after oral administration at a dose of 200 mg/kg in rats. Moreover, berberine concentrations remained relatively stable in liver, heart, brain, muscle, and pancreas tissue in rats (Tan et al., ).

However, recent studies on the distribution of berberine in vivo are rare, which may be attributed to the broad tissue distribution in vivo after oral administration. The availability of new technologies such as component analysis by high-performance liquid chromatography electrospray ionization mass spectrometry (HPLC&#;ESIMS)/mass spectrometry (MS) and MS imaging may permit improved exploration of the berberine tissue distribution (Jove et al., ). The fact that berberine is widely distributed in tissues may be useful in the treatment of some diseases, which may broaden the scope of its clinical application. For example, with the character of enrichment in the liver, oral treatment with 100 mg/kg berberine may promote the excretion of cholesterol from the liver to the bile (Li et al., b). Thus, distribution of berberine may be an important pharmacokinetic property requiring further study in future.

Metabolism

One study used a sensitive HPLC-ESIMS/MS method to identify the metabolites of berberine in human plasma, of which berberrubine was most abundant, with high lipid solubility in individuals who received 15 mg/kg oral berberine chloride per day for 3 months (Spinozzi et al., ). Evidence showed that berberine had a similar metabolic profile in rats (100 mg/kg administered orally) and humans (300 mg administered orally three times a day for 2 days) via the urine (Qiu et al., ). Using liquid chromatography coupled with ion trap time-of-flight mass spectrometry, Ma et al. () revealed that 16 separate metabolites could be identified in rat bile, urine, and feces samples after oral administration of berberine (200 mg/kg). After a single oral administration (48.2, 120, or 240 mg/kg) of berberine in rats, the levels of phase 2 metabolites were much higher than those of phase 1 metabolites for the AUC0&#;48 h values. Simultaneously, nine major metabolites of berberine (demethyleneberberine, jatrorrhizine-3-O-β-D-glucuronide, jatrorrhizine, berberrubine-9-O-β-D-glucuronide, jatrorrhizine-3-O-sulfate, berberrubine, thalfendine-10-O-β-D-glucuronide, demethyleneberberine-2-O-sulfate, and demethyleneberberine-2-O-β-D-glucuronide) were detected in rat serum using a LC&#;MS/MS method (Feng et al., ). Additionally, it was demonstrated that the metabolism of berberine by oral is closely related to liver function and gut microbiota. After oral administration of 300 mg/kg berberine in mice, cytochrome P3A11 (CYP3A11) and CYP3A25 mRNA and CYP3A11 and CYP2D22 enzyme activity levels were all found to be decreased, while the level of CYP1A2 mRNA was increased (Guo et al., ). Similarly, on oral administration of 200 mg/kg berberine in rats, the drug was shown to be metabolized in the liver by the CYP450 isoenzyme via oxidative demethylation at C2, C3, C9, and C10, followed by conjugation of the hydroxyl groups with glucuronic acid (Singh et al., ). Furthermore, gut microbiota can also affect the metabolism of berberine after oral administration. It was demonstrated that 200 mg/kg berberine administered orally could be converted into absorbable dihydroberberine by nitroreductases produced by gut microbiota, which showed a nearly 5-fold higher intestinal absorption rate than berberine in rats; the dihydroberberine is then oxidized back to berberine after absorption into the intestinal tissue, and enters the blood (Feng et al., ; Han et al., a). Also, gut microbiota was shown to convert berberine into oxyberberine through an oxidation reaction in vitro and in vivo, which exerted a much stronger binding interaction with hemoglobin than plasma (Li et al., a; Chen et al., ).

To summarize this section, the liver and intestine are the main metabolizing organs of berberine by oral administration. Inhibiting the first-pass effect may reduce the metabolism of berberine and improve its bioavailability. Interestingly, according to an in-depth study on the metabolism of berberine in vivo, it found that phase II metabolites are the major metabolic products of berberine (Feng et al., ), whereas the opposite was true in previous studies (Ma et al., ). In addition, particular attention should be paid to nitroreductases produced by gut microbiota, and berberine metabolism in general, in future studies, in order to fully establish the pharmacodynamic basis of this TCM.

Excretion

To better understand the poor absorption of berberine in vivo, some researchers have paid more attention to the excretion of berberine via the digestive tract. Berberine was found in feces with a recovery rate of 22.74% after a single oral dose (200 mg/kg) in 48 h, and thalifendine was the most abundant berberine metabolite excreted in the bile, urine, and feces in rats (Ma et al., ). In another study, 18.6% of the berberine was excreted in feces as berberrubine after intragastric administration at a single dose of 48.2 mg/kg. The total recovery of berberine and its metabolites from the urine, bile, and feces was 41.2% in rats (Feng et al., ). To summarize, berberine and its metabolites are mainly excreted by the kidneys (urine and feces) and bile in rats and mice (Liu et al., ).

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