Green Tea Extract

CAS No.: 56-81-5, -18-5, -60-2

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The extract of green tea boasts a myriad of benefits, largely attributed to its rich composition of polyphenols and methylxanthines. These polyphenols are key players in providing antioxidant and anti-inflammatory effects. Moreover, they possess the capacity to inhibit collagenase—the enzyme responsible for collagen breakdown and the degradation of vascular endothelium. Meanwhile, methylxanthines encourage vasodilatory responses and help prevent lipid accumulation within adipocytes. Furthermore, green tea extract offers protection against UVB-induced damage. Its applications are wide-ranging, including formulations for anti-cellulite therapies, sun protection, wrinkle reduction, and products aimed at soothing irritated or sensitive skin, alongside hair care solutions that enhance strength and shine.

This raw material is certified by ECOCERT Greenlife in compliance with the COSMOS Standard.

This cosmetic raw material is solely intended for external use in cosmetic formulations. It should not be ingested.

INCI: Glycerin (and) Water (and) Camellia Sinensis Leaf Extract

It is essential to incorporate this product into formulations at the advised usage rate.

Disclaimer 
The statements provided here have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, or prevent any disease. Always consult with a qualified skin care professional.

California Prop 65 Statement: This statement is issued following the California Safe Drinking Water and Toxic Enforcement Act of. The State of California does not recognize this product as a cause of cancer, birth defects, or other reproductive harm.

Metabolic syndrome is a collection of interrelated risk factors such as abdominal obesity, hypertension, high blood sugar levels, and abnormal lipid profiles, which presents a considerable public health concern globally. This intricate condition necessitates comprehensive interventions to lessen risks associated with cardiovascular diseases. As the landscape of metabolic syndrome management evolves, natural supplements have begun to draw attention for their beneficial roles. Among these, green tea extract stands out as a significant player. This article explores the advantages of incorporating green tea extract as a natural supplement within the context of this complex health issue.

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Defining Metabolic Syndrome

Metabolic syndrome is characterized by a combination of interconnected risk factors that elevate the chances of experiencing heart disease, stroke, and type 2 diabetes. To be diagnosed with metabolic syndrome, an individual must present at least three of the following five markers:

1. Abdominal obesity, assessed through waist measurements (over 35 inches for women and over 40 inches for men)
2. Elevated blood pressure (minimum of 130/85 mmHg)
3. High fasting blood sugar (100 mg/dL or above)
4. Elevated triglycerides (more than 150 mg/dL)
5. Low high-density lipoprotein (HDL) cholesterol (<50 mg/dL for women and <40 mg/dL for men)

Individuals suffering from metabolic syndrome are at a heightened risk of developing cardiovascular diseases due to the interplay of these factors. Increased abdominal obesity and insulin resistance foster chronic inflammation, negatively influencing lipid metabolism. This phenomenon further escalates the risk of atherosclerosis and significant cardiovascular events such as heart attacks and strokes.

Moreover, metabolic syndrome closely correlates with the onset of type 2 diabetes. Insulin resistance, a defining characteristic of this syndrome, disrupts normal blood sugar regulation, leading eventually to hyperglycemia.

To evaluate the risk of metabolic syndrome, advanced tests such as the Metabolomic Profile By Doctor's Data can help assess various biomarkers and provide insights into the likelihood of developing this syndrome.

An Overview of Green Tea Extract

Among the different varieties of tea, namely green, black, and oolong, green tea takes a prominent position. The extract is sourced from the leaves of Camellia sinensis, a plant indigenous to China. Traditionally, green tea has been employed over millennia as a stimulant, diuretic, astringent, and digestive aid. Recently, it has garnered considerable attention within scientific communities for its role in cancer prevention, cardiovascular support, and its anti-inflammatory, antioxidant, antibacterial, and neuroprotective properties.

The key bioactive components contributing to the beneficial effects of green tea extract are polyphenols, especially catechins, known for their powerful antioxidant capabilities. Essential catechins found in green tea include epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC), and epicatechin (EC). Green tea possesses a significantly higher catechin concentration compared to its black counterpart. Antioxidants play a vital role in eliminating reactive oxygen species, impeding free radical formation, and reducing inflammatory potential, ultimately lowering the risk of chronic diseases and premature aging.

Green Tea Extract's Role in Managing Metabolic Syndrome

Green tea extract has witnessed increased scrutiny concerning its potential benefits in tackling metabolic syndrome, with various scientific studies and clinical trials examining its effectiveness on pivotal factors such as blood sugar control, cholesterol profile, blood pressure, and weight management.

Research suggests that the bioactive compounds found in green tea, particularly EGCG, may be instrumental in enhancing blood sugar regulation. Studies indicate that regular green tea consumption can reduce the risk of developing type 2 diabetes. A cohort study involving Chinese adults—both diabetic and non-diabetic—demonstrated a link between daily green tea consumption and a reduced incidence of type 2 diabetes. Furthermore, diabetic patients who regularly consumed green tea exhibited a lower all-cause mortality risk compared to those who did not. A meta-analysis encompassing 17 randomized controlled trials revealed that green tea intake lowered fasting glucose by 0.09 mm/L, hemoglobin A1c by 0.3%, and fasting insulin by 1.16 μIU/mL.

On the cholesterol management front, the antioxidant properties of green tea catechins show considerable promise. Clinical studies indicate that green tea extract may aid in decreasing both total and LDL cholesterol levels, averaging reductions of 4.66 mg/dL and 4.55 mg/dL, respectively. Some studies even suggest that green tea may lower triglyceride levels.

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Additionally, research exploring green tea extract’s impact on blood pressure regulation has yielded notable findings. Epidemiological studies conducted in China found that consuming 120-599 mL or at least 600 mL of green tea daily corresponded to a 46% and 65% reduction in hypertension risk, respectively, compared to non-habitual tea drinkers. In patients with elevated blood pressure, the daily intake of green tea led to minor decreases in both systolic and diastolic blood pressure.

Green tea extract also appears to benefit weight management. Numerous studies have shown that overweight or obese individuals who consumed green tea or green tea extract, possessing 70-200 mg of caffeine and 576-886 mg of catechins daily over 12-24 weeks, achieved modest weight loss and reductions in visceral fat—averaging an additional 1.8 kg loss compared to their more sedentary counterparts.

Taken together, these effects are crucial in reducing cardiovascular risks associated with metabolic syndrome, with research indicating that daily consumption of three cups of green tea may lead to an 11% reduction in the incidence of myocardial infarction.

Mechanisms of Action Behind Green Tea Extract

Green tea extract exerts a positive influence on multiple components of metabolic syndrome through various mechanisms, each contributing to enhanced metabolic health.

Catechins found in green tea are believed to bolster insulin sensitivity by improving glucose absorption and insulin binding in adipocytes. Simultaneously, green tea extract significantly lowers blood sugar levels, a response similar to the hypoglycemic medication metformin, by boosting liver glycogen content and modulating key enzymes engaged in glucose metabolism. Furthermore, the water-soluble polysaccharide 7WA from green tea stimulates insulin secretion and exerts hypoglycemic effects via cAMP-PKA-dependent pathways, presenting another method for blood sugar regulation.

The vasodilatory effects exhibited by green tea catechins lead to improved endothelial function and reduced blood pressure. These components encourage nitric oxide release, a critical signaling molecule that relaxes blood vessels, bolstering cardiovascular health and alleviating hypertension often associated with metabolic syndrome.

Chronic inflammation plays a significant role in the onset and consequences of metabolic syndrome. Beyond its antioxidant benefits, green tea also has the capacity to modulate inflammatory responses by inhibiting the gene and protein expression of inflammatory cytokines and enzymes.

The synergistic presence of catechins and caffeine in green tea has been linked to enhanced thermogenic activity and fat oxidation. This results in a higher caloric burn and more efficient use of stored fat for energy, promoting effective weight management.

Dosage Guidelines for Green Tea Extract

Green tea can be utilized in various forms: as a beverage, powder, or extract. Typically, green tea extracts and drinks are standardized by their total catechin or EGCG content. The generally recommended dose of green tea extract ranges between 250-750 mg daily, which equates to approximately 2-3 cups of green tea.

As a beverage, green tea can be safely consumed in amounts up to eight cups per day. Individuals who are pregnant or breastfeeding should limit their intake to no more than six cups daily.

While adverse reactions to green tea are rare, it is essential to acknowledge their existence. Those sensitive to caffeine might experience insomnia, anxiety, irritability, heart palpitations, or digestive discomfort following green tea consumption. There have been a few isolated instances of liver damage associated with high doses of encapsulated green tea extract.

Furthermore, polyphenols and tannins found in tea can disrupt iron absorption; therefore, it is advisable to consume green tea separately from meals to avoid hindering iron uptake from food.

Incorporating Green Tea Extract with Lifestyle Modifications

To tackle metabolic syndrome effectively, a comprehensive lifestyle intervention strategy is essential, targeting modifiable risk factors such as obesity, Western dietary habits, and physical sedentary behavior. These elements create a robust foundation for successful treatment plans. Highlights include the importance of establishing sustainable healthy habits, promoting a heart-healthy diet, regular physical exercise, and maintaining a healthy weight.

Numerous studies correlate adherence to the Mediterranean diet—rich in dietary fiber, omega-3 and -9 fatty acids, complex carbohydrates, antioxidants, vitamins, and minerals—with improved cardiovascular health, owing to its positive effects on body mass, lipids, blood pressure, insulin resistance, and inflammation.

Engaging in regular physical activity confers significant benefits for cardiometabolic health, enhancing cardiovascular efficiency, improving insulin sensitivity, and fostering healthier lipid profiles. Physical activity is integral to mitigating metabolic syndrome risk factors, including obesity and hypertension, ultimately contributing to improved cardiovascular health. Notably, participants of the Korean National Health and Nutrition Examination Survey exhibiting physical activity at least weekly demonstrated significantly lower fasting glucose and waist circumference alongside increased HDL cholesterol compared to their inactive counterparts.

Modest weight reductions are linked to elevations in HDL cholesterol and reductions in LDL cholesterol, triglyceride levels, blood pressure, insulin resistance, and the risk of type 2 diabetes. A multifactorial approach, deploying diet, exercise, and behavioral counseling, offers the best chance for achieving weight loss objectives.

As individuals seek to embed these heart-healthy habits, supplementing with green tea extract alongside other dietary options and medications addressing blood pressure, cholesterol, and blood sugar might be beneficial for accelerating intended health results.

Challenges and Considerations

The efficacy of green tea extract in combating metabolic syndrome components appears variable based on scientific evidence. Although research suggests potential benefits, the individual responses can differ significantly. It is essential to understand that green tea extract is not a standalone treatment for metabolic syndrome; its incorporation into a comprehensive health plan should be personalized based on individual requirements and responses to the treatment. Engaging with healthcare professionals is vital to ascertain the optimal strategies tailored to specific health situations.

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Key Insights on Green Tea in Metabolic Syndrome Management

Green tea extract presents exciting prospects for managing diverse components of metabolic syndrome, including benefits associated with insulin sensitivity, glucose metabolism, and cardiovascular health. However, it is crucial to remember that individual reactions may vary, and green tea extract should complement, rather than replace, lifestyle measures. The focus should be on integrating natural supplements like green tea extract within a broader spectrum of lifestyle changes. Prioritizing a balanced diet, regular physical activity, and other evidence-based interventions facilitate a synergistic approach that optimizes health outcomes for those facing metabolic syndrome. By synergistically combining the advantages of green tea extract with comprehensive lifestyle modifications, individuals can build a foundation for sustained well-being and optimal metabolic health.

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