Ivermectin CAS No: 70288-86-7 Best Quality Assurance High ...
Ivermectin CAS No: 70288-86-7 Best Quality Assurance High ...
Ivermectin, with CAS number 70288-86-7, is widely recognized for its effectiveness in controlling a variety of parasitic infestations. Trusted sources highlight its application in both human and veterinary medicine, showcasing its broad-spectrum capability. This renowned antiparasitic agent has been deemed essential by health organizations worldwide, ensuring the highest quality assurance with every use.
Overview
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Ivermectin appears as a white crystalline powder, odorless and freely soluble in methanol, ethanol, acetone, and ethyl acetate, but practically insoluble in water. Additionally, it is slightly hygroscopic.
Composition and Properties
Ivermectin is a semisynthetic macrolide multi-component antibiotic. It mainly contains ivermectin B1 (B1a + B1b) with a content of not less than 93%, where the B1a content is not less than 85%.
Usage in Parasite Control
Ivermectin is routinely used for controlling parasitic worms in the gastrointestinal tract of ruminant animals. These parasites usually enter the animal when it is grazing, then pass through the bowel to mature in the intestines. The product is partially effective in killing these parasites and is also used as a prophylaxis against heartworm in dogs.
Mechanism of Action
This product has a selective inhibitory effect. It binds to high-affinity chloride channels with glutamate as the valve in nerve cells and muscle cells of spineless animals, increasing cell membrane permeability to chloride ions, leading to hyperpolarization, paralysis, or death of the parasites. It also interacts with chloride channels of other ligand valves, such as the neurotransmitter g-aminobutyric acid (GABA). Notably, some mammals lack glutamate-chloride channels, and ivermectin has a low affinity for mammalian ligand-chloride channels. The product cannot penetrate the human blood-brain barrier.
Applications in Treating Animal Diseases
Ivermectin is widely used to treat animals for diseases caused by roundworms and ectoparasites. For example, in veterinary medicine, it is used to prevent and treat heartworm and acariasis. It can be administered orally or topically for external infestations. Specific uses include the treatment of gastrointestinal nematodes, lungworms, and parasitic arthropods in cattle, sheep, horses, and pigs, as well as ear mites and Sarcoptes scabiei in dogs. Poultry also benefit from its use against gastrointestinal nematodes and ectoparasites.
Available Preparations
Ivermectin can be prepared in various forms, including:
- Ivermectin injection: 1%, 2%, 3.4%, 4%
- Ivermectin oral solution: 0.08%, 0.8%, 0.2%
- Ivermectin premix and bolus
- Ivermectin pour-on solution: 0.5%, 1%
- Ivermectin gel: 0.4%
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Additional reading:Dimethocaine | Inhibitor | Dopamine Receptor
Ivermectin - Substance Information - ECHA
The ‘Substance identity’ section calculated from ECHA databases includes the best available substance name, EC number, CAS number, and molecular and structural formulas for proper identification. Some identifiers may be confidential or not provided, and therefore not displayed.
EC (European Community) Number
The EC Number serves as the numerical identifier for substances in the EC Inventory which combines three independent European lists (EINECS, ELINCS, and NLP-list). ECHA attributes a list number for substances not covered by the EC Inventory.
CAS (Chemical Abstract Service) Registry Number
The CAS number is assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in their database. A substance identified by an EC or list number may have multiple CAS numbers or outdated ones.
Molecular Formula
This formula identifies each element by its chemical symbol and the number of atoms in one molecule of the substance. It's displayed if the substance is well-defined and not confidential.
Molecular Structure
The molecular structure is generated from information in ECHA's databases. An InChI string may also be generated if sufficient information is available. This information is displayed if the substance's identity is clear and not claimed confidential.
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