Collagen is becoming increasingly popular in the joint health market. Discover the benefits of native type II collagen for convenient and low-dose supplements.

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Widely used in beauty and cosmetics, as well as food and beverage applications, collagen is now making big moves in the joint health market, creating exciting opportunities for dietary supplement manufacturers to innovate in this sector.

Collagen is the main component of connective tissues that make up tendons, ligaments, skin and cartilage. Although it has many important functions in the body, collagen is best known for its structural role &#; providing a framework for tissues throughout the body.[1]&#;&#; Of the 28 different types of collagen that have been identified, type II collagen is the main structural protein in cartilage. Scientific evidence has demonstrated the effectiveness of native (undenatured) type II collagen in supporting joint health and may therefore be used as an ingredient in consumer products. 

However, the development of novel solutions with widely researched ingredients that are also easy to formulate is not a straightforward process. So how can manufacturers looking to make their next big move in the joint health market harness the powerful benefits of type II collagen?   

Joint health: a growing market &#;

The world&#;s population is ageing. Advances in healthcare and lifestyle improvements have contributed to increased longevity but as we age, our muscles, bones and joints can be impacted. In fact, 45% of individuals aged over 65      say they experience joint pain, which may affect their overall mobility and independence.[2]&#;&#; However, senior consumers are no longer taking mobility limitations sitting down. There is also an increasing interest in keeping fit and active as we age, with consumers starting to take a more proactive approach to protecting their joint health.

And it is not just the ageing population that are taking joint health more seriously. Several reports have shown that people who regularly play sport[3]&#;&#;, the 40-plus population[4]&#;&#;&#; and women experiencing menopause[5]&#;&#;&#; also suffer joint discomfort or mobility issues. These trends have given significant momentum to the joint health sector and are a major driving force in the emergence of innovative joint health solutions. Between and , it is forecast that the global bone and joint ingredients market will grow at a CAGR of 6.3% to meet this demand.[6]&#;&#;

Collagen for joint health&#;

Glucosamine and chondroitin have long been used as active ingredients for joint health. Recently, collagen has been rapidly gaining market share as a result of rising consumer awareness of the health benefits it delivers. According to recent market data, sales in the joint health market increased by 4.3 % in in the US alone, largely driven by a boost in collagen sales, which increased by 30%.[7]&#;&#; As a result, the joint health category has experienced its highest overall growth since .

Native type II collagen vs. hydrolysed type II collagen: what&#;s the difference?&#;

Both native (undenatured) type II collagen and hydrolysed (denatured) collagen are used in commercial joint health products, but there are significant differences between the two forms.

In its natural form, collagen has a folded triple helix structure consisting of long polypeptide chains (see figure 1). Hydrolysed collagen is manufactured via a specific hydrolysis process, where enzymes &#;cut&#; the triple helix molecule into smaller pieces, i.e. short-chain peptides. This is why hydrolysed collagen is also known as collagen peptides, or denatured type II collagen. Native type II collagen is not hydrolysed and maintains its characteristic three-dimensional structure.

 

Figure 1. The triple helix structure of native (undenatured) type II collagen &#;

Due to their structures, these two types of collagen also have different mechanisms of action. Native (undenatured) type II collagen works via an immune-mediated process, known as oral tolerance. Through this mode of action native type II collagen is recognised by the immune system as an endogenous substance, i.e. naturally occurring in the body, and deactivates the body&#;s immune response against its own collagen. On the other hand, hydrolysed collagen peptides are highly bioavailable, resulting in a source of the specific amino acids for de novo&#; synthesis of collagen. As such, hydrolysed collagen peptides act as building blocks to maintain and rebuild cartilage.

Effectiveness at lower doses &#;

The daily dose and intake required for both collagens to be effective in the body varies greatly. The native (undenatured) type II collagen form is required at doses as low as 40 mg/day. Meanwhile, the recommendation for hydrolysed collagen is 10 g/day (see figure 2). The low dosage required for native type II collagen therefore mirrors consumer demand for easy-to-consume, convenient products - offering an innovative alternative to supplement manufacturers.

Figure 2. Native type II collagen vs. hydrolysed collagen &#;

 &#;&#;

Exploring the link between immunity and joint health &#;

Joint disorders involving inflammation and cartilage erosion, such as arthritic diseases, are characterised by an autoimmune component in which the immune system acts against the body&#;s own type II collagen.[8]&#;&#; This is because products from collagen breakdown are recognised by immune cells as potential pathogens and are therefore considered harmful to the body. As a consequence, an inflammatory and cartilage degradation response is activated. This involves an immune response against endogenous type II collagen, further damaging cartilage in the body.

Native type II collagen has been shown to help modulate the immune response against endogenous type II collagen through its mode of action, thus reducing joint inflammation and cartilage degradation.[&#;9]&#;&#; When taken orally, native (undenatured) type II collagen passes through the stomach and reaches the intestine. It then interacts with the Peyer&#;s patches in the intestine, which are lymphoid nodules responsible for immune surveillance of the intestinal tract. This effectively turns off the immune response against endogenous type II collagen, helping to reduce joint inflammation and cartilage degradation.[10]&#;&#;

This mechanism of action means that only a small amount of native type II collagen to support joint health. This is why the standard dose of ingredients containing native collagen is just 40 mg, once daily, whereas dosages for hydrolysed collagen can be up to 10 g/day - an important benefit for manufacturers looking to meet the demand for effective, low-dose joint health solutions.

Mobilising the future with collagen&#;

Clinical studies demonstrate the efficacy of b-2Cool, a native (undenatured) type II collagen developed by Bioiberica. This natural-origin ingredient is extracted from chicken sternum and is manufactured in controlled conditions to maintain its characteristic triple helix structure and the specific active epitopes of the native protein.

The properties of native type II collagen position it as an effective ingredient for joint health solutions that are convenient, low-dose and reduce pill fatigue. As manufacturers look to develop the next innovation in joint health supplements, native type II collagen therefore represents an exciting opportunity to make a measurable difference in the mobility market.

 About Bioiberica:&#;

Bioiberica is a global Life Science company specialised in the identification, extraction and development of biomolecules of high biological and therapeutic value for the pharmaceutical and nutraceutical industries. This specialisation has positioned Bioiberica as the leading Heparin API manufacturer and a world reference in the research, production and sale of other biologically-derived APIS and ingredients such as Chondroitin Sulfate, Glucosamine, Hyaluronic Acid, Native Type II Collagen or Thyroid. Since , Bioiberica has consolidated its position as an expert in joint health and mobility thanks to a constant commitment to science and research.

 

These statements have not been evaluated by competent food authorities. This information is only for business-to-business use. The product is not intended to diagnose, treat, cure, or prevent &#;any disease.&#;

[1] M. Shoulders et al., &#;Collagen structure and stability&#;, Annu Rev Biochem&#;., vol. 78, pg. 929-958, .

[2] National Center for Health Statistics, United States, , Hyattsville, MD, .

[3] Cheng et al., &#;Journal of Clinical Epidemiology&#;, , vol. 53, pg. 315-322.

[4] National Center for Health Statistics. Health, United States, : Hyattsville, MD. .

[5] Estudio MMYA, Rodriguez Bueno E. et al. Congreso AEEM .

[6] https://mordorintelligence.com:81/industry-reports/bone-joint-health-ingredients-market&#;

[7] NBJ Condition Specific Report

[8] Kandahari, A. M. et al. Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis. J. Immunol. Res.&#;, pg. 1&#;13, .

[9] Park et al. Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis. Modern Rheumatology&#;, vol. 19, no. 6, pg. 581-589, .

[10] Ibid.

 

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Looking For An All Natural And Nutrient Dense Joint and Immune Health Formula?

Introducing &#; Perfect Type II Collagen

• New Zealand Pasture Raised, Grass-Fed Bovine Cartilage
• Rich In Type II Collagen
• Good Source of Chondroitin Sulfate
• Non-GMO
• Freeze Dried For Maximum Nutrient Value
• Nature&#;s Joint Health Formula
• 100% Pure Bovine Cartilage, Nothing Else Added
• The Only Glyphosate Residue Free Certified Cartilage

• 100% Money Back Guarantee
• 100% Natural and Pesticide and Hormone Free
• Lactose & Dairy Free
• Gluten Free & Soy Free
• Silver Level Green America Certified Business
• No Fillers of Flow Agents - Just Pure Grass-Fed Bovine Cartilage
• Industry Leading 3,200mg of Cartilage Per Serving
• The Only Bovine Cartilage to Receive Perfectly Pure Certification (learn more)

What&#;s All The Fuss About Collagen?

If you are new to collagen, be sure to read over our Perfect Hydrolyzed Collagen page, where we discuss all the health benefits of collagen and ways to increase your collagen levels to get a host of whole body benefits.

If you want to learn more, please visit our website hydrolyzed collagen type ii wholesalers.

The quick story on Collagen&#;

Collagen is the most abundant protein in the human body and plays a key role in numerous bodily functions. Found in our cartilage, collagen is literally the glue that holds our body together. The problem is, as we age, our collagen levels decrease.

When It Comes to Collagen, Type Matters

In truth, there is not one collagen, but at least 16 types of collagen.
While that information is useful if you are on a Quiz Show&#;



&#;it is not super important in your day to day activities
(unless you are training for a game show).
What is key to understand is that there are three main types of collagen.

Type I, II and III Collagen makeup 80-90% of the collagen in our body.

Type I and III are found in our skin, hair, nails, bones and fiber and are excellent for whole body health and wellness. Our Perfect Hydrolyzed Collagen is made with Type I and III collagen.

Type II Collagen is found in our cartilage and joints and can be extremely beneficial to people dealing with joint and immune issues.

Type II Collagen + X = Happy Joints

For people looking for joint health support, Type II Collagen is a solid choice&#; but it needs something else before it can be considered the perfect choice.

What is the X factor that Type II Collagen Needs?

The supporting cast of nutrients found in Bovine Cartilage!

Bovine Cartilage is an excellent source of Type II Collagen, but it also contains&#;

• Chondroitin Sulfate
• Proteoglycans
• Glycosaminoglycans
• Trace Minerals
• Bioactive Growth Factors
• Immunoregulators
• Undenatured Type II Collagen
• And many more micronutrients

Don&#;t worry, you don&#;t need to be an expert on proteoglycans (major kudos if you are) and all those other nutrients, the key point to understand is that Type II Collagen works much better when it has the support of ALL the nutrients found in bovine cartilage.

Bovine Cartilage, Nature&#;s First Aid Kit?

Humor me while I lay this out in an analogy&#;

Let&#;s say you take a spill and have a nasty cut on your knee. Two kind souls come up to you.

A nice chap named Mr. Col A. Gen offers you a band aid. That would certainly help with the bleeding.

But the always prepared Ms. Carti L. Age offers you a fully stocked First Aid kit. Hydrogen Peroxide to clean out the wound, some gauze, antibiotic ointment, even a butterfly stitch&#;and yes, plenty of band aids too.

The band aid from Col was nice, but of course you are going with the full First Aid kit from Carti. You are also a little concerned you have a concussion, and your hearing is off, since you have never met people with such odd names, but anyway&#;

Collagen is like the band aid, but Bovine Cartilage is the full first aid kit.

Does The Source of Bovine Cartilage Really Matter?

Now that we know that Bovine Cartilage is the most effective way to get on the road to healthy joints, the next question is&#; does it matter the source of the Bovine Cartilage?

You betcha!

We spent months talking to cartilage companies, reviewing lab assays and grilling suppliers on how their cattle are raised, fed and processed.

After all our research there were plenty of cartilage suppliers that we wouldn&#;t touch with a 100 foot pole, and one supplier that was&#; Perfect!

Perfect Type II Collagen &#; The Perfect Joint Health Formula

We are bursting with excitement about the creation of our Perfect Type II Collagen product. Developing a product is like putting a giant jigsaw puzzle together &#; all the pieces need to fit. Source, purity, testing, nutrient levels, processing and real world results &#; were the pieces - and they all fit Perfectly&#;

• New Zealand Pasture Raised Bovine Cartilage
• Freeze Dried For Maximum Nutrient Value
• All New Zealand Cows Are Grass-Fed and NON-GMO
• 3,200mg of Cartilage Per Serving
• 1,280mg of Type II Collagen Per Serving
• 575mg of Chondroitin Sulfate Per Serving
• Rich In All Micronutrients from Cartilage
• Nature&#;s Joint Health Formula

• 100% Pure, Nothing Else Added.
• 100% Money Back Guarantee
• 100% Natural and Pesticide and Hormone Free
• Lactose, Dairy, Gluten & Soy Free
• Silver Level Green America Certified Business
• No Fillers of Flow Agents - Just Pure Grass-Fed Bovine Cartilage
• The Only Glyphosate Residue Free Certified Cartilage
• The Only Bovine Cartilage to Receive Perfectly Pure Certification (learn more)

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IT'S NOT JUST PURE, IT'S PERFECTLY PURE

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IT'S NOT JUST PALEO, IT'S PERFECTLY PALEO

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Only paleo approved ingredients, no fake stuff,
lab tested, premium sources, and made with care.

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The World's First Certified Glyphosate Residue Free Cartilage and Type 2 Collagen

We are pleased to announce that Perfect Type II Collagen from Bovine Cartilage is the first and only cartilage collagen to receive the Glyphosate Residue Free Certification from the Detox Project.

In order to receive the Glyphosate Residue Free Certification from the Detox Project, Perfect Type II Collagen from Bovine Cartilage had to be tested by an ISO accredited lab and show no glyphosate residue down to the U.S.&#;s government-recognized limits of detection for food and supplements (0.01 ppm). After passing this initial test we agree to do spot testing of batches twice a year.

Click here if you want to learn more about why we consider this Glyphosate Residue Free Certification such an important part of what makes Perfect Type II Collagen&#; Perfect!

Try It Risk Free With Our 90 Day Money Back Guarantee

We know that trying is believing, so go ahead and use an entire bottle of the Perfect Type II Collagen. If for any reason you are not thrilled with the results, simply return the empty bottle within 90 days and get a full refund.

Click here to read about our Industry Leading Money Back Guarantee

 

A Perfect Partner For Our Perfect Type II Collagen

Want to take things to a whole other level of good?

Combine our Perfect Hydrolyzed Collagen with our Perfect Type II Collagen. This combo of grass-fed cartilage and multiple types of collagen is like a cheat code to optimal health. Except it&#;s not cheating, it is simply giving our body the nutrients it needs to feel its best.

 

Have Questions? Awesome, Let&#;s Chat

We totally get it, this stuff can get really confusing. Do you know how hard it was for us to spell Glycosaminoglycans correctly?

Seriously, anytime you are looking to ingest something, you deserve to have all your questions answered. Simply hit the Live Chat icon on the screen or Contact Us and let&#;s get you the information you need.

Perfect For All People And The Planet

We believe a supplement can only be called Perfect if it also supports the planet. Perfect Supplements always ensures their ingredients are fairly traded and harvested in a way that does not harm the planet.

We understand there are numerous companies that make supplements, but how many can list these credentials...

Click on any of the images above to verify the standing of our company. We don't just want to make the best Collagen supplement, we want to be the best natural product company for you and the planet.

Contact us to discuss your requirements of hydrolyzed collagen type ii exporter. Our experienced sales team can help you identify the options that best suit your needs.